Description

3,3-Difluorotetrahydro-2H-Pyran-4-Carboxylic Acid is a high-purity fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular scaffold, which incorporates both a carboxylic acid handle and a difluorinated tetrahydropyran ring, enabling the precise modulation of physicochemical properties in target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for developing novel active ingredients with improved metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, metabolic diseases, and anti-infectives.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the fluorine atoms and heterocyclic structure can enhance biological activity and environmental profile.
• Fluorine Chemistry & Material Science: Serves as a versatile precursor for creating fluorinated monomers, ligands, or complex organic frameworks with tailored electronic and surface properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated heterocycles under cGMP or ISO standards.
• Chemical Biology & Probe Development: Utilized in the design of molecular probes and biochemical tools where the difluoropyran moiety can act as a bioisostere or stability-enhancing motif.

Basic Information

Product Name	3,3-Difluorotetrahydro-2H-Pyran-4-Carboxylic Acid
CAS No.	1504681-05-3
Molecular Formula	C6H8F2O3
Molecular Weight	166.12 g/mol
Synonyms	4-Carboxy-3,3-difluorotetrahydropyran; 3,3-Difluoro-4-carboxytetrahydropyran; 3,3-Difluorotetrahydro-2H-pyran-4-carboxylic acid; 2H-Pyran-4-carboxylic acid, 3,3-difluorotetrahydro-; 1504681-05-3; 3,3-Difluorotetrahydropyran-4-carboxylic acid; 4-Pyrancarboxylic acid, 3,3-difluorotetrahydro-
EINECS	Contact for details

Quality Control

Our 3,3-Difluorotetrahydro-2H-Pyran-4-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, for comprehensive identity confirmation and impurity profiling. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, related substances, residual solvents, and water content. Our quality commitment aligns with the standards required for pharmaceutical development and other high-value applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and may require storage under an inert atmosphere for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.