Description

2-Fluoronicotinic Acid tert-Butyl Ester is a high-purity fluorinated pyridine derivative and a versatile building block in advanced organic synthesis. Its value lies in the strategic combination of a fluorinated nicotinic acid core with a tert-butyl ester protecting group, offering enhanced stability and reactivity for complex molecular construction. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, including kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and pesticides, where the fluorine atom can improve metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of fluorinated organic semiconductors and liquid crystals for electronic applications.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring precise fluorination and esterification chemistry.

Basic Information

Product Name	2-Fluoronicotinic Acid tert-Butyl Ester
CAS No.	1501904-78-4
Molecular Formula	C10H12FNO2
Molecular Weight	197.21 g/mol
Synonyms	tert-Butyl 2-fluoropyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 2-fluoro-, 1,1-dimethylethyl ester; 2-Fluoro-3-(tert-butoxycarbonyl)pyridine; 2-Fluoronicotinic acid tert-butyl ester; 2-Fluoropyridine-3-carboxylic acid tert-butyl ester; tert-Butyl 2-fluoronicotinate
EINECS	Contact for details

Quality Control

Our 2-Fluoronicotinic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider keeping the container under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.