Description

2-Chloro-5-Fluoropyridine-3-Boronic Acid Pinacol Ester is a high-value, organoboron building block essential for modern synthetic chemistry, particularly in cross-coupling reactions. Its core value lies in enabling the efficient and precise construction of complex heterocyclic scaffolds, which are critical in advanced material and pharmaceutical research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those containing fluorinated and chlorinated pyridine motifs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the specific halogenated pyridine structure imparts desired biological activity.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules and probes for studying biological systems and enzyme interactions.
• Custom Synthesis & Contract Manufacturing: A critical reagent for CROs and CDMOs offering bespoke chemical synthesis services to clients.
• Academic Research: Facilitates methodological development in organic synthesis and catalysis studies within university and institutional laboratories.

Basic Information

Product Name	2-Chloro-5-Fluoropyridine-3-Boronic Acid Pinacol Ester
CAS No.	1492890-58-0
Molecular Formula	C11H14BClFNO2
Molecular Weight	255.50 g/mol
Synonyms	(2-Chloro-5-fluoropyridin-3-yl)boronic acid pinacol ester; 2-Chloro-5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Boronic acid, 2-chloro-5-fluoropyridine-, pinacol ester; 2-Chloro-5-fluoropyridine-3-boronic acid neopentyl glycol ester (common alternative); 2-Chloro-5-fluoro-3-pyridineboronic acid pinacol ester; 1492890-58-0; Pinacol (2-chloro-5-fluoropyridin-3-yl)boronate
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoropyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically ≥95% (by HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation via NMR and LC-MS, and impurity profiles. We adhere to cGMP principles where applicable, and our quality management system is designed to meet the stringent requirements of pharmaceutical and advanced material supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.