Description

Cyclosporin A-Derivative 1 is a chemically modified analog of the well-known immunosuppressive cyclic peptide, Cyclosporin A. This derivative is engineered to offer researchers enhanced pharmacological properties or altered selectivity for specific biological targets, making it a critical tool for advanced drug discovery and development. It is primarily utilized by pharmaceutical R&D teams and academic institutions focused on immunology, autoimmune disease research, and novel therapeutic agent synthesis.

Application

• Immunosuppressive Research: Serves as a key reference compound for studying structure-activity relationships (SAR) and developing next-generation immunosuppressants with potentially improved efficacy or safety profiles.
• Drug Discovery & Development: Used as a synthetic intermediate or a lead compound in the design and optimization of novel therapeutic agents targeting calcineurin and related pathways.
• Biochemical Assays: Employed as a high-purity standard or probe in in vitro and cell-based assays to investigate T-cell activation, cytokine production, and other immune response mechanisms.
• Academic & Institutional Research: Supports fundamental research in immunology, transplant medicine, and autoimmune disorders at universities and research institutes.
• Process Chemistry & Scale-up: Acts as a model compound for developing and optimizing synthetic routes for complex cyclic peptides in pilot-scale manufacturing.

Basic Information

Product Name	Cyclosporin A-Derivative 1
CAS No.	1487360-85-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Cyclosporin A Analog; CsA Derivative 1; Cyclosporine A Derivative; Immunosuppressant Derivative; Cyclic Undecapeptide Derivative; [D-Ala8]-Cyclosporin A (example structural variant); Cyclosporin A Modification
EINECS	Contact for details

Quality Control

Our Cyclosporin A-Derivative 1 is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity analysis and structural confirmation, to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the product to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.