Description

Sodium Pregnenolone-17α,21,21,21-D4 Sulfate CAS NO 1485492-21-4 is a high-purity, deuterium-labeled analog of pregnenolone sulfate, a key neurosteroid precursor. This stable isotope-labeled compound is essential for precise quantitative analysis in research and development, offering unmatched accuracy as an internal standard in mass spectrometry. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and diagnostic developers working in neuroendocrinology, metabolomics, and drug discovery.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of endogenous pregnenolone sulfate in complex biological matrices like plasma, serum, and cerebrospinal fluid.
• Neurosteroid Research: Used in studies investigating the biosynthesis, metabolism, and physiological roles of neuroactive steroids in the central nervous system.
• Diagnostic Assay Development: Serves as a reference standard in the development and validation of clinical diagnostic tests for hormonal disorders.
• Pharmacokinetic & Metabolomic Studies: Enables precise tracking of drug metabolism and steroid pathway dynamics in preclinical and clinical research.
• Biomarker Discovery: Facilitates the identification and validation of steroid-based biomarkers for various neurological and endocrine conditions.
• Quality Control Reference: Employed as a certified reference material (CRM) to ensure the accuracy and reliability of analytical methods in QC laboratories.

Basic Information

Product Name	Sodium Pregnenolone-17α,21,21,21-D4 Sulfate
CAS No.	1485492-21-4
Molecular Formula	C21D4H28NaO5S
Molecular Weight	419.55 g/mol (approx.)
Synonyms	Pregnenolone-17α,21,21,21-d4 Sulfate Sodium Salt; [17α,21,21,21-2H4]-Pregnenolone Sulfate Sodium Salt; 3β-Hydroxy-5-pregnen-20-one-17α,21,21,21-d4 Sulfate Sodium Salt; Deuterated Pregnenolone Sulfate Sodium Salt; Sodium (3β,17α)-3-Hydroxy-21,21,21-trideuteriopregn-5-en-20-yl Sulfate; Pregnenolone-d4 Sulfate Sodium; Neurosteroid Precursor-d4 Sodium Salt; Internal Standard for Pregnenolone Sulfate
EINECS	Contact for details

Quality Control

Every batch of Sodium Pregnenolone-17α,21,21,21-D4 Sulfate is manufactured under strict quality management systems. We guarantee high chemical and isotopic purity, verified by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and solvent content is provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 5.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.