Description

Unc-0642 is a potent and selective small molecule inhibitor of the PRMT5 enzyme, a key epigenetic regulator. This compound is a critical research tool for investigating the role of protein arginine methylation in cellular processes such as transcription, splicing, and signal transduction. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology, epigenetics, and drug discovery programs.

Application

• Epigenetics Research: Used as a selective chemical probe to study the biological functions and mechanisms of Protein Arginine Methyltransferase 5 (PRMT5) and its impact on gene regulation.
• Oncology & Cancer Biology: Investigated for its potential to inhibit the growth of cancer cells, particularly those dependent on PRMT5 activity, such as certain leukemias and solid tumors.
• Drug Discovery & Development: Serves as a reference compound or lead structure in high-throughput screening and medicinal chemistry campaigns aimed at developing novel PRMT5-targeted therapeutics.
• Biochemical Assay Development: Employed as a standard inhibitor in enzymatic assays (e.g., ELISA, fluorescence polarization) to characterize PRMT5 activity and screen for new inhibitors.
• Cell Signaling Studies: Applied in cellular models to dissect signaling pathways influenced by arginine methylation and to understand downstream effects on cell proliferation, differentiation, and apoptosis.

Basic Information

Product Name	Unc-0642
CAS No.	1481677-78-4
Molecular Formula	C₂₃H₂₈N₆O₂
Molecular Weight	420.51 g/mol
Synonyms	UNC0642; GSK3326595; (R)-N-((1-(3,5-Difluorophenyl)-3-(pyridin-4-yl)-1H-pyrazol-5-yl)methyl)-2-methylpiperazine-1-carboxamide; PRMT5 Inhibitor VI; EPZ015666 analog; Protein arginine N-methyltransferase 5 inhibitor UNC0642
EINECS	Contact for details

Quality Control

Our Unc-0642 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for research use. A detailed Certificate of Analysis (COA) specifying batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. The compound is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.