Description

Ripk1-In-4 is a potent and selective small molecule inhibitor of the Receptor-interacting serine/threonine-protein kinase 1 (RIPK1). This compound matters as a critical research tool for investigating the role of RIPK1 in regulating necroptosis and inflammation, pathways implicated in various diseases. It is needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel therapeutics for inflammatory, neurodegenerative, and autoimmune conditions.

Application

• Biochemical Research: Used as a selective probe to study RIPK1 kinase activity and its downstream signaling pathways in vitro.
• Cell-Based Assays: Employed to inhibit RIPK1-driven necroptosis in cellular models of disease, helping to validate therapeutic targets.
• Preclinical Drug Discovery: Serves as a reference compound or a starting point for structure-activity relationship (SAR) studies in medicinal chemistry programs.
• Inflammation & Immunology Studies: Applied in research models to dissect the contribution of RIPK1 to inflammatory responses and immune disorders.
• Neurodegenerative Disease Research: Utilized in models of conditions like ALS and multiple sclerosis to explore the neuroprotective effects of RIPK1 inhibition.

Basic Information

Product Name	Ripk1-In-4
CAS No.	1481641-08-0
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.42 g/mol
Synonyms	RIPK1-IN-4; RIPK1 Inhibitor IV; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 6-(4-fluorophenyl)-N,1-diphenyl-; 6-(4-Fluorophenyl)-N,1-diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine; CAS 1481641-08-0
EINECS	Contact for details

Quality Control

Our Ripk1-In-4 is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.