Description

Nrf1-Activator-1 CAS NO 1474034-05-3 is a potent and selective small molecule activator of the Nuclear factor erythroid 2-related factor 1 (Nrf1) transcription factor, a key regulator of cellular antioxidant and proteasome gene expression. This compound is a critical research tool for investigating the Nrf1 signaling pathway, which is implicated in cellular stress response, protein homeostasis, and various disease states. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on neurodegenerative diseases, cancer biology, and metabolic disorders.

Application

• Biochemical Research: A key reagent for studying the molecular mechanisms of the Nrf1-mediated antioxidant response and proteasome biogenesis.
• Drug Discovery: Used as a lead compound or pharmacological probe in high-throughput screening and target validation for diseases involving oxidative stress and proteotoxic stress.
• Neurodegenerative Disease Models: Applied in cellular and animal models of Alzheimer's, Parkinson's, and ALS to investigate Nrf1's role in neuroprotection.
• Cancer Biology Studies: Utilized to explore the dual role of Nrf1 in tumor suppression and oncogenesis within various cancer cell lines.
• Metabolic Disorder Research: Investigates the connection between Nrf1 activation, metabolic regulation, and conditions like diabetes and fatty liver disease.
• Cell Signaling Pathway Analysis: Serves as a specific activator to dissect Nrf1's interaction with other pathways like the Unfolded Protein Response (UPR).

Basic Information

Product Name	Nrf1-Activator-1
CAS No.	1474034-05-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Nrf1 Activator 1; NFE2L1 Activator 1; 1474034-05-3; Nrf1-Activator1; Nrf1 inducer; TC-G 1008; LDN-0198960; (2E)-3-[5-(2,3-Dimethoxyphenyl)-2-furanyl]-N-hydroxy-2-propenamide (IUPAC-based)
EINECS	Contact for details

Quality Control

Our Nrf1-Activator-1 is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and analytical data is provided with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.