Description

Pyridostatin Tfa Salt is a high-purity, small-molecule compound recognized for its potent and selective activity as a G-quadruplex stabilizer. This specificity makes it a critical research tool for investigating DNA secondary structures and their roles in cellular processes, particularly in oncology and molecular biology. It is essential for pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on telomere biology, gene expression regulation, and the development of novel therapeutic strategies targeting genomic instability.

Application

• Biochemical Research: A key reagent for studying the structure, function, and biological relevance of G-quadruplex DNA in vitro and in cellular models.
• Oncology & Cancer Biology: Used to investigate the role of G-quadruplexes in telomere maintenance, oncogene expression (e.g., c-MYC, KRAS), and as a potential chemotherapeutic target.
• Drug Discovery & Development: Serves as a reference compound and pharmacophore model for designing new G-quadruplex-interactive agents with improved potency and selectivity.
• Molecular Pharmacology: Employed in assays to understand the mechanisms of transcription and replication inhibition mediated by G-quadruplex stabilization.
• Academic Research: Fundamental studies in nucleic acid chemistry, biophysics, and genome architecture to elucidate the biological consequences of G-quadruplex formation.

Basic Information

Product Name	Pyridostatin Tfa Salt
CAS No.	1472611-44-1
Molecular Formula	C₂₀H₂₀F₃N₅O₅
Molecular Weight	467.39 g/mol
Synonyms	Pyridostatin trifluoroacetate salt; N-(2-(Pyridin-2-ylamino)ethyl)-3-(quinolin-4-ylamino)propanamide trifluoroacetate; G-quadruplex stabilizer Pyridostatin; 4-((3-((2-(Pyridin-2-ylamino)ethyl)amino)-3-oxopropyl)amino)quinoline trifluoroacetate
EINECS	Contact for details

Quality Control

Our Pyridostatin Tfa Salt is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support research compliance with traceable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.