Description

Atglistatin is a potent and selective small-molecule inhibitor of adipose triglyceride lipase (ATGL), a key enzyme in lipid metabolism. This compound is of significant value for research focused on understanding and modulating intracellular fat breakdown and energy homeostasis. It is primarily utilized by pharmaceutical researchers and academic institutions engaged in metabolic disease studies, obesity research, and the development of novel therapeutic agents targeting lipolysis.

Application

• Biochemical Research: A critical tool for studying the role of ATGL in cellular lipolysis, lipid droplet biology, and energy balance in vitro and in vivo.
• Metabolic Disease Modeling: Used to create pharmacological models of impaired lipolysis to investigate conditions like cachexia, heart failure, and certain metabolic disorders.
• Drug Discovery & Validation: Serves as a reference compound and pharmacological probe for validating ATGL as a drug target and screening for new inhibitors.
• Academic & Preclinical Studies: Employed in university and institutional labs for fundamental research into fat metabolism, signaling pathways, and related physiological processes.

Basic Information

Product Name	Atglistatin
CAS No.	1469924-27-3
Molecular Formula	C₂₀H₂₀N₂O₃
Molecular Weight	336.39 g/mol
Synonyms	Atglistatin; 2-[(2,4-Dichlorophenyl)methyl]-3-(2-thienylmethyl)-4(3H)-quinazolinone; ATGL Inhibitor; Adipose Triglyceride Lipase Inhibitor; 1469924-27-3; 2-[(2,4-Dichlorophenyl)methyl]-3-(thiophen-2-ylmethyl)quinazolin-4(3H)-one
EINECS	Contact for details

Quality Control

Our Atglistatin is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research applications. Each batch is accompanied by comprehensive analytical documentation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.