Description

K-Ras(G12C) Inhibitor 9 is a potent and selective small molecule inhibitor designed to target the oncogenic KRAS G12C mutant protein. This compound is a critical research tool and a lead candidate in the development of targeted cancer therapies, offering a direct approach to treating tumors driven by this specific mutation. It is essential for pharmaceutical R&D, academic research, and preclinical development programs focused on lung, colorectal, and pancreatic cancers.

Application

• Oncology Research & Drug Discovery: Primary tool compound for studying KRAS G12C signaling pathways and validating drug targets.
• Preclinical Development: Used as a reference standard or lead molecule in the development of novel anti-cancer therapeutics.
• Biochemical Assays: Serves as a key reagent in high-throughput screening (HTS) and enzymatic inhibition studies.
• Cell-Based Studies: Applied in vitro to assess effects on proliferation, apoptosis, and downstream signaling in cancer cell lines.
• Pharmacology & Toxicology: Utilized in ADME (Absorption, Distribution, Metabolism, Excretion) and PK/PD (Pharmacokinetics/Pharmacodynamics) profiling.
• Chemical Biology: Probe molecule for understanding protein-ligand interactions and structure-activity relationships (SAR).

Basic Information

Product Name	K-Ras(G12C) Inhibitor 9
CAS No.	1469337-91-4
Molecular Formula	C30H30F2N6O3
Molecular Weight	560.60 g/mol
Synonyms	ARQ-751; ARQ751; ARQ 751; KRAS G12C Inhibitor ARQ-751; (S)-N-(1-(2-(2,6-Difluorophenyl)acetyl)-1,2,3,4-tetrahydroquinolin-6-yl)-2-((6-methoxy-2-methyl-4-(1-methyl-1H-pyrazol-5-yl)quinolin-3-yl)oxy)acetamide; ARQ751; K-Ras(G12C) Inhibitor 9; KRAS G12C inhibitor 9
EINECS	Contact for details

Quality Control

Our K-Ras(G12C) Inhibitor 9 is manufactured under strict quality systems suitable for research and development. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) with detailed specifications are provided to ensure traceability and batch-to-batch consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.