Description

6-Hydroxy-Levonorgestrel is a key pharmaceutical intermediate and active metabolite of the synthetic progestogen levonorgestrel. This compound is of significant importance for research and development in the fields of endocrinology, steroid chemistry, and pharmaceutical manufacturing. It serves as a critical building block for scientists and manufacturers developing advanced hormonal therapies, diagnostic assays, and novel drug delivery systems. The global availability of this high-purity intermediate supports innovation in women's health and contraceptive technology.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of advanced steroid-based APIs and prodrugs.
• Metabolite Reference Standard: Essential for analytical method development and validation in bioanalytical studies and pharmacokinetic research.
• Biochemical Research: Used in studies investigating the metabolism, receptor binding, and pharmacological activity of progestogens.
• Diagnostic Kit Development: Serves as a key component in the manufacture of immunoassay kits for hormone level monitoring.
• Quality Control & Impurity Profiling: Employed as a certified reference material (CRM) for impurity identification and assay standardization in QC laboratories.

Basic Information

Product Name	6-Hydroxy-Levonorgestrel
CAS No.	1458616-80-2
Molecular Formula	C₂₁H₂₈O₃
Molecular Weight	328.45 g/mol
Synonyms	6α-Hydroxylevonorgestrel; 13-Ethyl-17-hydroxy-18,19-dinor-17α-pregn-4-en-20-yn-3-one, 6α-hydroxy-; Levonorgestrel 6α-ol; 6-Hydroxy LNG; 6α-Hydroxy-13-ethyl-17-hydroxy-18,19-dinor-17α-pregn-4-en-20-yn-3-one
EINECS	Contact for details

Quality Control

Our 6-Hydroxy-Levonorgestrel is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and detailed Certificates of Analysis (COA) to support your regulatory and research requirements. Specifications can be tailored to meet specific pharmacopeial standards (e.g., USP reference standards grade) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.