Description

5-Bromo-2-Fluoro-3-Formylphenylboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring bromo, fluoro, and formyl substituents on a phenylboronic acid core, makes it an exceptionally versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for applications such as Suzuki-Miyaura cross-coupling and further functional group transformations.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic acid functional group enables efficient palladium-catalyzed carbon-carbon bond formation with various aryl/heteroaryl halides, essential for creating biaryl structures.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the creation of organic electronic materials, such as those for organic light-emitting diodes (OLEDs) and semiconductors, where the halogen and formyl groups allow for precise tuning of electronic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	5-Bromo-2-Fluoro-3-Formylphenylboronic Acid
CAS No.	1451393-09-1
Molecular Formula	C7H5BBrFO3
Molecular Weight	245.83 g/mol
Synonyms	(5-Bromo-2-fluoro-3-formylphenyl)boronic acid; 3-Borono-5-bromo-2-fluorobenzaldehyde; 5-Bromo-2-fluoro-3-formylbenzeneboronic acid; Boronic acid, B-(5-bromo-2-fluoro-3-formylphenyl)-; 2-Fluoro-5-bromo-3-formylphenylboronic acid; 3-Formyl-5-bromo-2-fluorophenylboronic acid; CAS 1451393-09-1
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-Fluoro-3-Formylphenylboronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and scale-up applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request. Our quality protocols are designed to support compliance with cGMP and ICH guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.