Description

2-Fluoro-5-Methoxypyridine-4-Boronic Acid is a high-purity boronic acid derivative, a crucial building block in modern synthetic organic chemistry. Its value lies in its role as a key intermediate for constructing complex molecules via cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), particularly in drug discovery and development programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, enabling the introduction of the pyridine scaffold with specific substitutions.
• Material Science Research: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials through palladium-catalyzed cross-coupling.
• Suzuki-Miyaura Cross-Coupling: The quintessential application, enabling the formation of carbon-carbon bonds to attach the pyridine moiety to aromatic and heteroaromatic systems with high efficiency.
• Chemical Biology & Probe Development: Utilized in synthesizing molecular probes and bioconjugates for studying biological processes and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and libraries for high-throughput screening.

Basic Information

Item	Details
Product Name	2-Fluoro-5-Methoxypyridine-4-Boronic Acid
CAS No.	1451392-17-8
Molecular Formula	C6H7BFNO3
Molecular Weight	170.94 g/mol
Synonyms	(2-Fluoro-5-methoxypyridin-4-yl)boronic acid; 4-Borono-2-fluoro-5-methoxypyridine; 2-Fluoro-5-methoxy-4-pyridineboronic acid; 5-Methoxy-2-fluoropyridine-4-boronic acid; 2-Fluoro-5-methoxypyridine-4-boronohydride; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluoro-5-methoxypyridine (Pinacol ester precursor); 1451392-17-8 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Methoxypyridine-4-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.