Description

Ddr1-In-1 CAS NO 1449685-96-4 is a potent and selective small molecule inhibitor of the Discoidin Domain Receptor 1 (DDR1), a key tyrosine kinase receptor involved in cell adhesion, migration, and extracellular matrix remodeling. This compound is a critical research tool for investigating the role of DDR1 signaling pathways in various physiological and pathological processes. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, fibrosis, and inflammatory disease research.

Application

• Biochemical Research: Used as a selective probe to study DDR1 kinase function and signaling cascades in vitro.
• Oncology Research: Investigated for its potential to inhibit tumor progression, metastasis, and the tumor microenvironment where DDR1 is overexpressed.
• Fibrosis Studies: Applied in research models for lung, liver, and kidney fibrosis to understand DDR1's role in collagen deposition and tissue scarring.
• Inflammation Research: Utilized to explore the connection between DDR1 and inflammatory responses in autoimmune and chronic inflammatory diseases.
• Drug Discovery: Serves as a lead compound or reference standard in high-throughput screening and structure-activity relationship (SAR) studies for novel DDR1 inhibitors.
• Cell Biology: Employed to dissect mechanisms of cell-collagen interactions, cell migration, and epithelial-to-mesenchymal transition (EMT).

Basic Information

Product Name	Ddr1-In-1
CAS No.	1449685-96-4
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	DDR1-IN-1; DDR1 Inhibitor; 7-(3-(4-(2-Methoxyphenyl)piperazin-1-yl)propoxy)-4-methyl-2H-chromen-2-one; 4-Methyl-7-[3-[4-(2-methoxyphenyl)-1-piperazinyl]propoxy]-2H-1-benzopyran-2-one; DDR1 kinase inhibitor; Discoidin Domain Receptor 1 Inhibitor
EINECS	Contact for details

Quality Control

Our Ddr1-In-1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation. The compound is stable under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.