Description

(R,S,R)-2-Acetyl-4-(1,2,3,4-Tetrahydroxybutyl)-Imidazole-13C6 is a stable isotope-labeled analog of a key advanced glycation endproduct (AGE) precursor, specifically enriched with carbon-13 at six positions. This compound serves as a critical internal standard for the precise quantification and mechanistic study of AGEs in complex biological matrices using mass spectrometry. It is essential for researchers and quality control laboratories in the pharmaceutical, diagnostic, and life science sectors who require high-fidelity analytical standards for metabolic disorder research, diabetes studies, and anti-aging product development.

Application

• Mass Spectrometry Internal Standard: Used as a quantitative reference standard in LC-MS/MS and GC-MS analyses for accurate measurement of unlabeled AGE precursors in biological samples.
• Diabetes & Metabolic Research: Enables detailed investigation into the formation pathways and kinetics of advanced glycation endproducts, which are implicated in diabetic complications.
• Pharmaceutical R&D: Supports drug discovery programs targeting AGE inhibition by providing a labeled tracer for pharmacokinetic and metabolic studies.
• Diagnostic Assay Development: Crucial for calibrating and validating clinical diagnostic kits designed to measure glycation biomarkers in serum or plasma.
• Nutritional & Anti-Aging Studies: Facilitates research into the effects of diet and supplements on the body's glycation processes.
• Stable Isotope Labeling Studies: Serves as a tracer in metabolic flux analysis to map biochemical pathways related to carbohydrate metabolism.

Basic Information

Product Name	(R,S,R)-2-Acetyl-4-(1,2,3,4-Tetrahydroxybutyl)-Imidazole-13C6
CAS No.	1448358-08-4
Molecular Formula	C913C6H16N2O5
Molecular Weight	~286.25 g/mol (for 13C6 labeled form)
Synonyms	2-Acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole-13C6; ATI-13C6; 3DG Precursor-13C6; (R,S,R)-2-Acetyl-4-(tetrahydroxybutyl)imidazole-13C6; 1-(4,5-Dihydro-1H-imidazol-2-yl)-2,3,4,5-tetrahydroxypentan-1-one-13C6; Isotopically Labeled AGE Precursor; Carbon-13 Labeled Imidazole Derivative
EINECS	Contact for details

Quality Control

Every batch of (R,S,R)-2-Acetyl-4-(1,2,3,4-Tetrahydroxybutyl)-Imidazole-13C6 is manufactured and analyzed under strict quality protocols to ensure the highest isotopic and chemical purity for analytical applications. Our quality system ensures compliance with relevant standards for high-purity reference materials. Comprehensive Certificates of Analysis (COA) are provided, detailing isotopic enrichment (typically ≥99 atom % 13C), chemical purity (by HPLC), and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at 2-8°C. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥99 atom % 13C
Isotopic Purity (MS)	≥99% 13C6
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.