Description

(2S,4R)-1-((S)-2-Amino-3,3-Dimethylbutanoyl)-4-Hydroxy-n-(4-(4-Methylthiazol-5-Yl)Benzyl)Pyrrolidine-2-Carboxamide Hydrochloride is a high-purity, non-natural amino acid derivative and a key pharmaceutical intermediate. This compound is of significant commercial interest due to its role as a critical building block in the synthesis of complex therapeutic agents, particularly protease inhibitors. It is primarily required by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the development and production of novel drug candidates.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly for antiviral and anticancer therapies.
• Protease Inhibitor Development: Serves as a core structural component in the research and production of novel protease inhibitor drugs.
• Peptidomimetic Research: Used in medicinal chemistry for designing and synthesizing peptide-like molecules with enhanced stability and bioavailability.
• Bioconjugation & Labeling: The reactive functional groups make it suitable for creating targeted drug conjugates or diagnostic agents.
• Chemical Biology Probes: Employed in academic and industrial research to study enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Supplied for optimization and kilogram-scale production under current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Product Name	(2S,4R)-1-((S)-2-Amino-3,3-Dimethylbutanoyl)-4-Hydroxy-n-(4-(4-Methylthiazol-5-Yl)Benzyl)Pyrrolidine-2-Carboxamide Hydrochloride
CAS No.	1448189-80-7
Molecular Formula	C24H35N5O3S • HCl
Molecular Weight	518.10 g/mol
Synonyms	Boc-protected amino acid derivative (related precursor); (2S,4R)-1-[(2S)-2-Amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide hydrochloride; PF-07321332 Intermediate (related compound); Nirmatrelvir Intermediate (related compound); SARS-CoV-2 3CLpro Inhibitor Intermediate; Pyrrolidine carboxamide derivative hydrochloride salt; 5-Thiazolebenzyl pyrrolidinecarboxamide
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality systems suitable for pharmaceutical applications. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. We provide full traceability and detailed Certificates of Analysis (COA) that document identity, assay, impurity profile, residual solvents, and other critical parameters. Quality is managed in alignment with ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.