Description

2-(Difluoromethyl)Pyridin-4-Amine is a specialized pyridine derivative featuring a difluoromethyl substituent, serving as a critical building block in advanced organic synthesis. Its unique fluorinated structure is engineered to enhance molecular properties such as metabolic stability and lipophilicity, making it invaluable for creating novel compounds. This high-purity intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of novel pesticides and herbicides, where the difluoromethyl group can improve biological activity and environmental stability.
• Material Science Research: Employed as a precursor for developing specialty chemicals, liquid crystals, or advanced polymers with tailored properties.
• Chemical Biology Probes: Serves as a building block for synthesizing fluorinated probes and tags used in bioimaging and diagnostic assay development.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	2-(Difluoromethyl)Pyridin-4-Amine
CAS No.	1446509-58-5
Molecular Formula	C6H6F2N2
Molecular Weight	144.12 g/mol
Synonyms	4-Amino-2-(difluoromethyl)pyridine; 2-(Difluoromethyl)-4-pyridinamine; 4-Pyridinamine, 2-(difluoromethyl)-; 2-Difluoromethylpyridin-4-ylamine
EINECS	Contact for details

Quality Control

Every batch of 2-(Difluoromethyl)Pyridin-4-Amine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.