Description

6-Trifluoromethyl-2-Chloropyridine-4-Boronic Acid is a high-value, multi-functional boronic acid derivative essential for modern synthetic chemistry. Its core value lies in its dual functionality, serving as a versatile building block for constructing complex molecules via cross-coupling reactions like the Suzuki-Miyaura reaction. This compound is critically needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients, particularly those requiring the unique properties of the trifluoromethyl and chloropyridine motifs.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura cross-coupling to form biaryl and heterobiaryl structures, a cornerstone of modern C-C bond formation.
• Chemical Biology & Proteomics: Can be utilized in the synthesis of molecular probes and affinity tags for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	6-Trifluoromethyl-2-Chloropyridine-4-Boronic Acid
CAS No.	1446486-10-7
Molecular Formula	C6H4BClF3NO2
Molecular Weight	225.36 g/mol
Synonyms	2-Chloro-6-(trifluoromethyl)pyridine-4-boronic acid; (2-Chloro-6-(trifluoromethyl)pyridin-4-yl)boronic acid; 4-Borono-2-chloro-6-trifluoromethylpyridine; 2-Chloro-4-pyridineboronic acid, 6-(trifluoromethyl)-; 6-Trifluoromethyl-2-chloro-4-pyridineboronic acid; 2-Chloro-6-trifluoromethyl-4-pyridinylboronic acid; 1446486-10-7
EINECS	Contact for details

Quality Control

Our 6-Trifluoromethyl-2-Chloropyridine-4-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) and handle it in a controlled, low-humidity environment to maintain stability and purity. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.