Description

Gpr84 Antagonist 8 is a potent and selective small molecule inhibitor of the G-protein coupled receptor 84 (GPR84), a key target in inflammatory and metabolic research. This high-purity compound is essential for preclinical studies investigating the role of GPR84 signaling pathways in various disease models. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on immunology, fibrosis, and metabolic disorders.

Application

• Pharmacological Research Tool: Used as a selective antagonist to elucidate the physiological and pathological roles of the GPR84 receptor in cellular and animal models.
• Inflammation and Immunology Studies: Critical for investigating GPR84-mediated inflammatory responses, including macrophage activation and cytokine release.
• Metabolic Disorder Research: Applied in studies exploring the receptor's function in insulin resistance, adipose tissue inflammation, and related metabolic pathways.
• Fibrosis and Tissue Remodeling: Utilized in research targeting GPR84 involvement in fibrotic diseases of the liver, lung, and other organs.
• Neuroinflammation: Employed in neurological research to study the receptor's potential role in neuroinflammatory conditions.
• Lead Compound Optimization: Serves as a reference or starting point for medicinal chemistry programs aimed at developing novel GPR84-targeted therapeutics.
• High-Throughput Screening (HTS): Used as a control compound in assay development and validation for drug discovery campaigns.

Basic Information

Product Name	Gpr84 Antagonist 8
CAS No.	1445846-30-9
Molecular Formula	C₂₀H₂₀N₄O₃S
Molecular Weight	396.46 g/mol
Synonyms	8-(4-Chlorophenyl)-2-((2-methoxy-4-(methylsulfonyl)phenyl)amino)-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one; GPR84 antagonist; GPR84 inhibitor 8; GPR84 Antagonist Compound 8; 1445846-30-9; 8-(4-Chlorophenyl)-2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-5-one
EINECS	Contact for details

Quality Control

Our Gpr84 Antagonist 8 is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.