Description

Deltarasin (Hydrochloride) is a potent and selective small molecule inhibitor of the KRAS-PDEδ protein-protein interaction. This compound is of significant interest in oncology research due to its role in disrupting the oncogenic signaling of mutant KRAS, a key driver in many aggressive cancers. It serves as a critical research tool for pharmaceutical R&D, academic institutions, and biotechnology companies focused on developing novel targeted cancer therapies and understanding RAS pathway biology.

Application

• Oncology Research & Drug Discovery: Primary tool compound for studying KRAS signaling inhibition and validating PDEδ as a therapeutic target.
• Biochemical Assay Development: Used as a reference standard in high-throughput screening (HTS) and binding assays to identify new KRAS-PDEδ inhibitors.
• Cell Biology Studies: Investigation of downstream effects of KRAS pathway disruption on cell proliferation, apoptosis, and migration in various cancer cell lines.
• Preclinical In Vivo Research: Evaluation of pharmacokinetics, pharmacodynamics, and efficacy in relevant animal models of KRAS-driven cancers.
• Mechanism of Action (MoA) Studies: Elucidation of the structural and functional aspects of the KRAS-PDEδ interaction complex.
• Chemical Biology Probes: Serves as a starting point for the development of tagged or fluorescent derivatives for cellular imaging and target engagement studies.

Basic Information

Product Name	Deltarasin (Hydrochloride)
CAS No.	1440898-82-7
Molecular Formula	C31H34ClN5O3 • HCl
Molecular Weight	596.55 g/mol
Synonyms	Deltarasin HCl; 2-[(3-Chloro-4-methylphenyl)amino]-N-[[4-[[(3S)-3-(dimethylamino)-1-pyrrolidinyl]carbonyl]phenyl]methyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide hydrochloride; PDEδ inhibitor; KRAS-PDEδ interaction inhibitor; KRAS signaling inhibitor
EINECS	Contact for details

Quality Control

Our Deltarasin (Hydrochloride) is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive biological research. Each batch is accompanied by comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (Mass Spec)	Consistent with molecular structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.