Description

Deltarasin CAS NO 1440898-61-2 is a potent and selective small-molecule inhibitor of the KRAS-PDEδ protein-protein interaction, a critical target in oncology research. This compound matters for its role in disrupting the oncogenic signaling of mutant KRAS, a key driver in many aggressive and difficult-to-treat cancers. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel targeted cancer therapies and investigating RAS pathway biology.

Application

• Oncology Research & Drug Discovery: A key tool compound for studying KRAS-dependent signaling pathways and validating PDEδ as a therapeutic target.
• Preclinical Development: Used in in vitro and in vivo studies to assess the efficacy and mechanism of action of KRAS-PDEδ inhibition.
• Chemical Biology: Serves as a probe to understand the cellular localization and function of KRAS and its interaction partners.
• High-Throughput Screening (HTS): Can be used as a reference standard or positive control in assays designed to discover new KRAS-PDEδ inhibitors.
• Combinatorial Therapy Studies: Investigated for potential synergistic effects when used alongside other targeted agents or chemotherapeutics.
• Biomarker Research: Aids in identifying and validating predictive biomarkers for patient stratification in potential future clinical trials.

Basic Information

Product Name	Deltarasin
CAS No.	1440898-61-2
Molecular Formula	C₂₉H₃₀N₄O₃
Molecular Weight	482.57 g/mol
Synonyms	Deltarasin; 2-[(3S)-3-[[4-(3,4-Dihydro-2H-1-benzopyran-6-yl)-2-pyridinyl]amino]-1-pyrrolidinyl]-4-(4-methyl-1-piperazinyl)pyrimidine-5-carboxamide; KRAS-PDEδ inhibitor; PDEδ-KRAS interaction inhibitor; (S)-2-(3-((4-(3,4-Dihydro-2H-chromen-6-yl)pyridin-2-yl)amino)pyrrolidin-1-yl)-4-(4-methylpiperazin-1-yl)pyrimidine-5-carboxamide
EINECS	Contact for details

Quality Control

Our Deltarasin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity determination and MS, NMR for structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and other critical quality attributes is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.