Description

Clindamycin (2R-Cis)-Diastereomer is a specific stereoisomeric form of the lincosamide antibiotic clindamycin, identified by CAS NO 1440605-46-8. This high-purity diastereomer is critical for pharmaceutical research and development, particularly in the study of structure-activity relationships, metabolic pathways, and the synthesis of novel antibiotic derivatives. It serves as an essential reference standard and advanced intermediate for manufacturers and research institutions focused on antimicrobial agents and stereochemistry.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control of clindamycin-based drug products.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key chiral building block in the sophisticated synthesis of novel lincosamide antibiotics and prodrugs.
• Metabolic and Pharmacokinetic Studies: Employed in research to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of specific clindamycin stereoisomers.
• Impurity Profiling and Identification: Essential for identifying, quantifying, and controlling stereoisomeric impurities in clindamycin API batches to ensure compliance with pharmacopeial standards (USP, EP).
• Academic and Industrial Research: A vital tool for studying antibiotic mechanism of action, resistance mechanisms, and for the discovery of new therapeutic agents targeting bacterial protein synthesis.

Basic Information

Product Name	Clindamycin (2R-Cis)-Diastereomer
CAS No.	1440605-46-8
Molecular Formula	C18H33ClN2O5S
Molecular Weight	424.98 g/mol
Synonyms	(2R,4S)-Clindamycin; (2R-Cis)-Clindamycin; Clindamycin Diastereomer; 7(S)-Chloro-7-deoxylincomycin; Methyl 7-chloro-6,7,8-trideoxy-6-[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-L-threo-α-D-galacto-octopyranoside (2R-cis isomer); U-28508; Antibiotic U-28508; Cleocin Diastereomer
EINECS	Contact for details

Quality Control

Our Clindamycin (2R-Cis)-Diastereomer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for diastereomeric purity, NMR for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure compliance with research and pharmaceutical grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Diastereomeric Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.