Description

4-Fluoro-3-Formylphenylacetylene is a high-value, multi-functional aromatic building block featuring both an aldehyde and an acetylene group on a fluorinated benzene ring. This unique bifunctional structure makes it a critical intermediate for synthesizing complex molecules in advanced research and development. It is primarily utilized by pharmaceutical, agrochemical, and material science industries for constructing novel compounds, including active pharmaceutical ingredients (APIs), liquid crystals, and organic electronic materials.

Application

• Pharmaceutical Intermediate: Key synthon for the construction of novel drug candidates, particularly in kinase inhibitor and targeted therapy research.
• Agrochemical Synthesis: Used in developing new generation herbicides and fungicides with enhanced efficacy.
• Material Science: Building block for organic semiconductors, liquid crystals (LCs), and advanced polymers due to its conjugated system.
• Chemical Research: Serves as a versatile precursor for Sonogashira coupling, click chemistry, and other palladium-catalyzed cross-coupling reactions.
• Fluorescent Probe Development: Utilized in synthesizing fluorophores and molecular sensors for bioimaging and diagnostics.

Basic Information

Product Name	4-Fluoro-3-Formylphenylacetylene
CAS No.	1440535-11-4
Molecular Formula	C9H5FO
Molecular Weight	148.14 g/mol
Synonyms	3-Ethynyl-4-fluorobenzaldehyde; 4-Fluoro-3-ethynylbenzaldehyde; 4-Fluoro-3-formylphenylacetylene; 3-Formyl-4-fluorophenylacetylene; 4-Fluoro-3-ethynylbenzenecarboxaldehyde; 4-Fluoro-3-(ethynyl)benzaldehyde; 3-Ethynyl-4-fluorobenzenecarboxaldehyde
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Formylphenylacetylene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.