Description

6-Fluoro-2-(Piperidin-4-Yl)-2,3-Dihydro-1H-Isoindol-1-One is a high-purity, advanced pharmaceutical intermediate of significant interest in modern drug discovery. This compound, with CAS number 1439902-96-1, is valued for its unique heterocyclic scaffold that incorporates both a fluorinated isoindolinone and a piperidine moiety, offering a versatile platform for medicinal chemistry. It is primarily sought by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel drug candidates, especially for CNS-targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its privileged scaffold.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degraders.
• Kinase Inhibitor Synthesis: Employed in the development of small molecule inhibitors for various kinase targets.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP or research-grade conditions.

Basic Information

Product Name	6-Fluoro-2-(Piperidin-4-Yl)-2,3-Dihydro-1H-Isoindol-1-One
CAS No.	1439902-96-1
Molecular Formula	C13H15FN2O
Molecular Weight	234.27 g/mol
Synonyms	2-(4-Piperidinyl)-6-fluoro-2,3-dihydro-1H-isoindol-1-one; 6-Fluoro-2-(4-piperidinyl)-2,3-dihydro-1H-isoindol-1-one; 6-Fluoro-2-(piperidin-4-yl)isoindolin-1-one; 6-Fluoro-2-(4-piperidyl)-2,3-dihydro-1H-isoindol-1-one; 1439902-96-1; 6-Fluoro-2-(piperidin-4-yl)-2,3-dihydro-1H-isoindol-1-one; 2,3-Dihydro-6-fluoro-2-(4-piperidinyl)-1H-isoindol-1-one
EINECS	Contact for details

Quality Control

Our 6-Fluoro-2-(Piperidin-4-Yl)-2,3-Dihydro-1H-Isoindol-1-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including research-grade and cGMP-grade material for advanced development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.