Description

Methyl (R)-1-Boc-3-Fluoropyrrolidine-3-Carboxylate is a high-value, chiral fluorinated pyrrolidine derivative, serving as a critical advanced intermediate in modern organic synthesis. Its core value lies in providing a protected, stereodefined scaffold for the efficient construction of complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise building blocks for drug discovery programs targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated pyrrolidine motifs.
• Protease Inhibitor Development: Used in the research and production of inhibitors for various proteases, where the fluorinated pyrrolidine core is a common pharmacophore.
• Building Block for Bioactive Molecules: Employed in the construction of potential drug candidates for central nervous system (CNS) disorders, oncology, and antiviral therapies.
• Agrochemical Synthesis: Serves as an intermediate in the development of novel, fluorinated agrochemicals with enhanced properties.
• Methodology & Library Synthesis: A valuable reagent in academic and industrial research for developing new synthetic methodologies and generating diverse compound libraries for screening.
• Peptidomimetics: Integral to the design and synthesis of peptidomimetic compounds, where it can mimic natural amino acid structures with improved metabolic stability.

Basic Information

Product Name	Methyl (R)-1-Boc-3-Fluoropyrrolidine-3-Carboxylate
CAS No.	1438852-70-0
Molecular Formula	C12H20FNO4
Molecular Weight	261.29 g/mol
Synonyms	(R)-Methyl 1-(tert-butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylate; (R)-1-Boc-3-fluoro-3-(methoxycarbonyl)pyrrolidine; tert-Butyl (3R)-3-fluoro-3-(methoxycarbonyl)pyrrolidine-1-carboxylate; (R)-1-Boc-3-fluoropyrrolidine-3-carboxylic acid methyl ester; Methyl (3R)-1-(tert-butoxycarbonyl)-3-fluoropyrrolidine-3-carboxylate; (R)-3-Fluoro-1-Boc-pyrrolidine-3-carboxylic acid methyl ester; (3R)-1-Boc-3-fluoropyrrolidine-3-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl (R)-1-Boc-3-Fluoropyrrolidine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and standard spectroscopic methods for identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment aligns with the standards required for cGMP and non-GMP pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is sensitive to strong acids and should be kept away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.