Description

Ldn 193189 Hydrochloride is a potent and selective small molecule inhibitor of the BMP (Bone Morphogenetic Protein) type I receptors ALK2 and ALK3. This compound is a critical research tool for modulating the BMP signaling pathway, which plays a fundamental role in stem cell differentiation, bone formation, and embryonic development. It is essential for researchers and developers in the fields of regenerative medicine, developmental biology, and oncology research, where precise control of cell fate is required.

Application

• Stem Cell Research & Differentiation: Used to inhibit BMP signaling to promote the maintenance of pluripotency in embryonic stem cells (ESCs) or to direct differentiation toward specific lineages.
• Developmental Biology Studies: A key reagent for investigating the role of BMP pathways in embryonic patterning, organogenesis, and tissue morphogenesis.
• Bone Disease & Osteogenesis Research: Employed in studies aiming to understand and potentially treat conditions related to aberrant bone formation or heterotopic ossification.
• Cancer Research: Investigated for its effects on cancer cell proliferation, metastasis, and tumor microenvironment, particularly in cancers where BMP signaling is dysregulated.
• High-Throughput Screening (HTS): Serves as a reference compound or positive control in assays designed to discover novel BMP pathway modulators.
• Biochemical & Cellular Assay Development: Used to validate assay systems and establish dose-response curves for BMP receptor kinase activity.

Basic Information

Product Name	Ldn 193189 Hydrochloride
CAS No.	1435934-00-1
Molecular Formula	C₂₆H₂₆N₄O₂ • HCl
Molecular Weight	462.97 g/mol (as hydrochloride salt)
Synonyms	LDN-193189 HCl; LDN193189 hydrochloride; DM-3189; 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline hydrochloride; BMP Inhibitor LDN 193189 HCl; ALK2/ALK3 Inhibitor; Dorsomorphin analog hydrochloride
EINECS	Contact for details

Quality Control

Our Ldn 193189 Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. A detailed Certificate of Analysis (COA) providing full specifications and analytical data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (Mass Spec)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.