Description

Creb Inhibitor (666-15) is a potent and selective small molecule inhibitor of the cAMP response element-binding protein (CREB) signaling pathway. This compound is crucial for researchers investigating gene regulation, neuronal plasticity, and oncology, as it allows for precise modulation of CREB-mediated transcription. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics for cancer, neurological disorders, and metabolic diseases.

Application

• Biomedical Research: A key tool compound for studying the role of CREB in cellular signaling, gene expression, and disease mechanisms in vitro and in vivo.
• Oncology Research: Investigation of CREB's function in tumor growth, survival, and metastasis, particularly in cancers where this pathway is dysregulated.
• Neuroscience Research: Exploration of CREB's critical role in memory formation, synaptic plasticity, and neuronal survival.
• Drug Discovery: Used as a pharmacological probe in high-throughput screening (HTS) and lead optimization campaigns targeting the CREB pathway.
• Metabolic Disease Studies: Research into CREB's involvement in glucose homeostasis, lipid metabolism, and related disorders.
• Biochemical Assay Development: Serves as a reference standard and positive control in developing assays for kinase and transcription factor activity.

Basic Information

Product Name	Creb Inhibitor (666-15)
CAS No.	1433286-70-4
Molecular Formula	C23H21N5O3S
Molecular Weight	447.51 g/mol
Synonyms	666-15; CREB Inhibitor 666-15; 2-(4-((4-(4-Methylpiperazin-1-yl)phenyl)amino)quinazolin-6-yl)phenol; N-[4-(1H-Benzimidazol-2-yl)phenyl]-2-furamide; CREB pathway inhibitor; cAMP response element-binding protein inhibitor
EINECS	Contact for details

Quality Control

Our Creb Inhibitor (666-15) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Custom synthesis and purification to meet specific project requirements (e.g., >98% or >99% purity) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.