Description

Nicardipine-D3 is a deuterium-labeled analog of the calcium channel blocker nicardipine, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is essential for ensuring accuracy and reliability in pharmacokinetic and metabolic studies, where precise measurement is critical. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities involved in drug development and bioanalysis.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the accurate quantification of nicardipine in biological matrices such as plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to track the absorption, distribution, metabolism, and excretion (ADME) of nicardipine, enabling precise pharmacokinetic profiling.
• Bioanalytical Method Development and Validation: A key component in developing, validating, and ensuring the reproducibility of robust bioanalytical assays for regulatory submissions.
• Clinical Research: Supports clinical trials by providing a reliable standard for monitoring nicardipine levels in patient samples, ensuring data integrity.
• Pharmaceutical Quality Control: Can be utilized in impurity profiling and stability-indicating methods for nicardipine drug substances and products.
• Forensic and Toxicological Analysis: Aids in the precise detection and quantification of nicardipine in forensic investigations or cases of suspected overdose.

Basic Information

Product Name	Nicardipine-D3
CAS No.	1432061-50-1
Molecular Formula	C26H26D3N3O6
Molecular Weight	~479.53 g/mol
Synonyms	Nicardipine-d3; 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-[2-(N-benzyl-N-methylamino)]ethyl ester 5-methyl ester-d3; Deuterated Nicardipine; Nicardipine (phenyl-d3); 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-[methyl(phenyl-d3)amino]ethyl ester; (±)-Nicardipine-d3
EINECS	Contact for details

Quality Control

Our Nicardipine-D3 is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity, essential for reliable analytical results. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing specifications for isotopic enrichment (Chemical Purity ≥98%, Isotopic Purity ≥99% D), identity confirmation, and impurity profiles. We adhere to relevant industry guidelines for reference standards to support your compliance needs in GLP and GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or Certificate of Analysis. This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to light yellow powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99.0 atom % D
Chemical Purity	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.