Description

Way-267464 Dihydrochloride is a high-purity, non-peptide selective oxytocin receptor antagonist used in advanced pharmacological research. This compound is critical for investigating the role of oxytocin pathways in neurobiology, social behavior, and potential therapeutic applications. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) focused on central nervous system (CNS) disorders and behavioral pharmacology.

Application

• Neuroscience Research: A key tool for studying the function of the oxytocin receptor (OTR) in the brain and its modulation of social cognition, anxiety, and stress responses.
• Psychiatric Disorder Models: Used in preclinical research to explore the therapeutic potential of OTR antagonism for conditions such as autism spectrum disorders (ASD), schizophrenia, and addiction.
• Pharmacological Profiling: Serves as a reference standard in in vitro binding assays and functional studies (e.g., calcium mobilization, GTPγS) to characterize receptor selectivity and potency.
• Drug Discovery & Development: Employed in hit-to-lead optimization and as a pharmacological probe to validate OTR as a target in new therapeutic programs.
• Behavioral Pharmacology: Essential for in vivo studies investigating the effects of oxytocin signaling on pair bonding, maternal behavior, and aggression in animal models.
• Biochemical Reagent: Used as a controlled reagent in the development of diagnostic assays and high-throughput screening (HTS) platforms targeting neuropeptide receptors.

Basic Information

Product Name	Way-267464 Dihydrochloride
CAS No.	1432043-31-6
Molecular Formula	C₂₀H₂₈Cl₂N₄O₃
Molecular Weight	443.37 g/mol
Synonyms	Way 267464 dihydrochloride; L-371,257; (1-(4-Chlorophenyl)-1H-pyrrol-3-yl)(3S,4R)-3-(2-methoxyphenyl)-1-(2-(pyrrolidin-1-yl)ethyl)-4-(thiophen-2-yl)pyrrolidine-2,5-dione dihydrochloride; 1-(4-Chlorophenyl)-1H-pyrrol-3-yl)(3S,4R)-3-(2-methoxyphenyl)-1-[2-(1-pyrrolidinyl)ethyl]-4-(2-thienyl)-2,5-pyrrolidinedione dihydrochloride; Oxytocin receptor antagonist Way-267464; Non-peptide oxytocin antagonist.
EINECS	Contact for details

Quality Control

Every batch of Way-267464 Dihydrochloride is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with standards expected for pharmaceutical reference materials and advanced research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.