Description

Wehi-539 CAS NO 1431866-33-9 is a potent and selective small-molecule inhibitor of Bcl-2 family proteins, specifically targeting Bcl-xL. This compound is a critical research tool for investigating the mechanisms of apoptosis and cellular survival pathways. It is primarily utilized by researchers and scientists in the fields of oncology, biochemistry, and molecular biology for drug discovery and target validation studies.

Application

• Biomedical Research: Fundamental studies on apoptosis regulation, Bcl-2 protein family interactions, and programmed cell death mechanisms.
• Oncology Research: Investigation of cancer cell survival dependencies and validation of Bcl-xL as a therapeutic target in various cancer models.
• Drug Discovery & Development: Used as a reference compound or pharmacological tool in high-throughput screening and lead optimization campaigns for novel anti-cancer agents.
• Cell Biology Studies: Exploration of cellular stress responses and the role of anti-apoptotic proteins in cell culture systems.
• Chemical Biology: Probe compound for understanding protein-protein interaction networks and signaling pathways involving Bcl-2 family members.

Basic Information

Product Name	Wehi-539
CAS No.	1431866-33-9
Molecular Formula	C30H31N5O3S
Molecular Weight	541.66 g/mol
Synonyms	WEHI-539; Bcl-xL inhibitor WEHI-539; 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(2R)-4-morpholinylmethyl]phenyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide; (R)-N-((4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)sulfonyl)-3-((4-morpholinobenzyl)amino)phenyl)methanesulfonamide (trifluoroacetate salt)
EINECS	Contact for details

Quality Control

Our Wehi-539 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity verification and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.