Description

Lsd1-In-1 CAS NO 1431326-61-2 is a potent and selective small-molecule inhibitor of the lysine-specific demethylase 1 (LSD1) enzyme, a key epigenetic regulator. This compound is a critical research tool for investigating the role of LSD1 in gene expression, cellular differentiation, and disease pathways, particularly in oncology and neurobiology. It is essential for pharmaceutical R&D, academic research, and biotechnology companies focused on developing novel epigenetic therapies and understanding disease mechanisms.

Application

• Biochemical Research: Used as a reference standard and probe compound in enzymatic assays to study LSD1 inhibition kinetics and mechanism of action.
• Epigenetics & Cell Biology: A key tool for modulating histone methylation marks in cell culture models to elucidate the role of LSD1 in stem cell pluripotency, differentiation, and cellular reprogramming.
• Oncology Research: Investigated in preclinical studies for its potential to inhibit the growth and metastasis of various cancers, including acute myeloid leukemia (AML), breast cancer, and prostate cancer, by targeting LSD1 activity.
• Neuroscience Research: Applied in models to explore the function of LSD1 in neural development, synaptic plasticity, and neurodegenerative or psychiatric disorders.
• Drug Discovery & Development: Serves as a lead compound or pharmacophore model for the design and optimization of new therapeutic agents targeting epigenetic enzymes.
• High-Throughput Screening (HTS): Utilized as a control compound in screening campaigns to identify novel LSD1 inhibitors from chemical libraries.

Basic Information

Product Name	Lsd1-In-1
CAS No.	1431326-61-2
Molecular Formula	C21H19F3N4O2
Molecular Weight	416.40 g/mol
Synonyms	LSD1-IN-1; (E)-N-((5-(3-(3-Fluorophenyl)acryloyl)-2-methoxyphenyl)methyl)-4-methylpiperazine-1-carboxamide; GSK-LSD1; GSK2879552 analog; Lysine-specific demethylase 1 inhibitor 1; KDM1A inhibitor
EINECS	Contact for details

Quality Control

Our Lsd1-In-1 is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, potency, and full analytical data are provided and available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under desiccated conditions. Allow the product to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.