Description

Ddr1-In-2 is a potent and selective small-molecule inhibitor of the Discoidin Domain Receptor 1 (DDR1), a key tyrosine kinase receptor implicated in extracellular matrix remodeling and cellular signaling pathways. This compound is a critical research tool for investigating the role of DDR1 in various physiological and pathological processes, including fibrosis, inflammation, and cancer progression. It is essential for pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on target validation and preclinical drug discovery.

Application

• Biomedical Research: Used as a selective pharmacological probe to study DDR1 kinase signaling pathways and their biological functions in cell-based assays.
• Drug Discovery & Development: Serves as a reference compound or lead molecule in high-throughput screening and structure-activity relationship (SAR) studies for novel DDR1 inhibitors.
• Oncology Research: Investigated for its potential to inhibit tumor growth, metastasis, and the epithelial-mesenchymal transition (EMT) in various cancer models where DDR1 is overexpressed.
• Fibrosis Studies: Applied in research models of renal, pulmonary, and hepatic fibrosis to elucidate the role of DDR1 in collagen deposition and tissue scarring.
• Inflammation & Immunology: Utilized to explore the involvement of DDR1 in immune cell recruitment and inflammatory responses in autoimmune and chronic inflammatory diseases.
• Biochemical Assay Development: Acts as a control inhibitor in enzymatic (kinase) and cellular assays to establish assay robustness and specificity for DDR1.

Basic Information

Product Name	Ddr1-In-2
CAS No.	1429617-90-2
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	DDR1-IN-2; DDR1 Inhibitor 2; 7-Methyl-2-[[(3S)-3-(1H-pyrazol-1-ylmethyl)pyrrolidin-1-yl]methyl]-4-(4-morpholinyl)pyrido[4,3-d]pyrimidine; UNII-9R3J3B4Q6G; 9R3J3B4Q6G; BDBM50230275; HY-101877; AOB8378; CS-1386
EINECS	Contact for details

Quality Control

Our Ddr1-In-2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and Karl Fischer titration for water content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.