Description

Methylene Calcitriol CAS NO 1428946-52-4 is a chemically modified analog of calcitriol, the active form of Vitamin D3. This compound is of significant interest for its potential to modulate Vitamin D receptor (VDR) activity with altered pharmacokinetic and pharmacodynamic profiles. It is primarily utilized by pharmaceutical researchers and manufacturers in the development of novel therapeutics targeting metabolic bone diseases, psoriasis, and certain cancers.

Application

• Pharmaceutical Research & Development: A key intermediate or active pharmaceutical ingredient (API) in the synthesis of novel Vitamin D analogs.
• Metabolic Bone Disease Studies: Investigated for potential applications in treating osteoporosis, renal osteodystrophy, and hypoparathyroidism.
• Dermatology Drug Development: Used in research for creating new topical or systemic treatments for psoriasis and other hyperproliferative skin disorders.
• Oncology Research: Explored for its antiproliferative and differentiating effects in preclinical studies of various cancers, including prostate and breast cancer.
• Biochemical Tool Compound: Serves as a selective ligand in molecular biology to study Vitamin D receptor signaling pathways and gene regulation.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Methylene Calcitriol
CAS No.	1428946-52-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(22E)-26,27-Cyclo-9,10-secocholesta-5,7,10(19),22-tetraene-1α,3β,25-triol; 1α,25-Dihydroxy-26,27-cyclo-22-ene-vitamin D3; 26,27-Cyclo-22-ene-calcitriol; Methylene-seco-calcitriol analog
EINECS	Contact for details

Quality Control

Our Methylene Calcitriol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., argon or nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.