Description

3-(Difluoromethyl)Piperidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. Its value lies in the strategic incorporation of the difluoromethyl group, a key motif for modulating the physicochemical and metabolic properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disease research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the difluoromethyl group can enhance biological activity and stability.
• Chemical Biology & Proteomics: Serves as a valuable scaffold or labeling reagent in the design of enzyme inhibitors and molecular probes.
• Material Science Research: Employed in the synthesis of specialty chemicals and functionalized polymers requiring specific fluorine-containing motifs.
• Custom Synthesis & Process Development: A key starting material for contract research organizations (CROs) and CDMOs engaged in route scouting and scale-up projects.

Basic Information

Product Name	3-(Difluoromethyl)Piperidine Hydrochloride
CAS No.	1427455-16-0
Molecular Formula	C6H12ClF2N
Molecular Weight	171.62 g/mol
Synonyms	3-(Difluoromethyl)piperidine HCl; Piperidine, 3-(difluoromethyl)-, hydrochloride; 3-Difluoromethylpiperidine hydrochloride; 3-(Difluoromethyl)piperidinium chloride
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethyl)Piperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment supports applications requiring material of high and reliable purity for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.