Description

2-Methyl-5-Phenyl-1,3-Oxazole-4-Sulfonyl Chloride is a specialized sulfonyl chloride derivative, a key reactive intermediate in modern synthetic organic chemistry. Its primary value lies in its role as a versatile sulfonylation reagent, enabling the efficient introduction of the sulfonyl functional group into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that incorporate sulfonyl moieties for enhanced activity.
• Material Science Research: Employed in the development of novel polymers, dyes, and functional materials where sulfonylation modifies physical or chemical properties.
• Chemical Biology & Proteomics: Serves as a reactive handle for labeling or modifying biomolecules in probe development and activity-based protein profiling (ABPP).
• Custom Synthesis & Contract Manufacturing: A valuable reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing high-value, complex molecules for clients.

Basic Information

Product Name	2-Methyl-5-Phenyl-1,3-Oxazole-4-Sulfonyl Chloride
CAS No.	1427380-74-2
Molecular Formula	C10H8ClNO3S
Molecular Weight	257.69 g/mol
Synonyms	4-(Chlorosulfonyl)-2-methyl-5-phenyl-1,3-oxazole; 5-Phenyl-2-methyl-1,3-oxazole-4-sulfonyl chloride; 2-Methyl-5-phenyloxazole-4-sulfonyl chloride; Oxazole-4-sulfonyl chloride, 2-methyl-5-phenyl-; 1427380-74-2
EINECS	Contact for details

Quality Control

Every batch of 2-Methyl-5-Phenyl-1,3-Oxazole-4-Sulfonyl Chloride is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.