Description

3-Fluoro-4-Methoxypicolinonitrile is a high-value, multi-functional heterocyclic building block. This compound is critical for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, due to its reactive nitrile group and substituted pyridine core. It is primarily sought after by research chemists and process development scientists for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its fluorine and methoxy substituents for bioactivity.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands used in catalysis and material science.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Advanced Material Development: A starting material for synthesizing functionalized heterocycles used in electronic materials or organic semiconductors.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific research and scale-up projects.

Basic Information

Product Name	3-Fluoro-4-Methoxypicolinonitrile
CAS No.	1427357-47-8
Molecular Formula	C7H5FN2O
Molecular Weight	152.13 g/mol
Synonyms	4-Methoxy-3-fluoropicolinonitrile; 3-Fluoro-4-methoxypyridine-2-carbonitrile; 2-Cyano-3-fluoro-4-methoxypyridine; 3-Fluoro-4-methoxy-2-pyridinecarbonitrile; Picolinonitrile, 3-fluoro-4-methoxy-; 1427357-47-8
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Methoxypicolinonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.