Description

5-Fluoro-2-Hydroxypyridine-4-Boronic Acid is a high-value, multi-functional heterocyclic building block essential for modern synthetic chemistry. Its core value lies in the strategic combination of a boronic acid group for Suzuki-Miyaura cross-coupling reactions and a fluorinated hydroxypyridine scaffold, enabling the precise construction of complex molecular architectures. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated pyridine cores found in active pharmaceutical ingredients (APIs), including kinase inhibitors and antiviral agents.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that benefit from the fluorinated heterocycle's metabolic stability and bioavailability.
• Suzuki-Miyaura Cross-Coupling: The boronic acid functionality makes it an ideal coupling partner with aryl/heteroaryl halides for creating biaryl and heterobiaryl linkages under palladium catalysis.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized bidentate or tridentate ligands used in homogeneous catalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs or conductive polymers, where fluorination tunes electronic properties.
• Chemical Biology Probes: Useful for synthesizing fluorinated molecular probes and tags for studying biological systems and enzyme mechanisms.

Basic Information

Product Name	5-Fluoro-2-Hydroxypyridine-4-Boronic Acid
CAS No.	1427305-76-7
Molecular Formula	C5H5BFNO3
Molecular Weight	156.91 g/mol
Synonyms	(5-Fluoro-2-hydroxypyridin-4-yl)boronic acid; 4-Borono-5-fluoro-2-hydroxypyridine; 5-Fluoro-2-hydroxy-4-pyridineboronic acid; 5-Fluoro-2-oxo-1,2-dihydropyridine-4-boronic acid; 5-Fluoro-4-pyridone-2-boronic acid; 5-Fluoro-2(1H)-pyridone-4-boronic acid; 5-Fluoro-2-hydroxypyridine-4-boronic acid pinacol ester (common protected form)
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Hydroxypyridine-4-Boronic Acid is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance for critical synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-98%)
Water Content (KF)	≤ 2.0%
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.