Description

4-(1-Fluoro-1-Methyl-Ethyl)-Pyrimidine-5-Carbaldehyde is a high-value, fluorinated pyrimidine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers developing novel active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of a fluorine atom and an aldehyde functional group enables precise molecular modifications. Its primary value lies in facilitating the creation of complex molecules with enhanced biological activity and metabolic stability for the pharmaceutical and agrochemical industries.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in constructing advanced fungicides, herbicides, and insecticides, where the fluorinated pyrimidine core contributes to improved efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of organic electronic materials and liquid crystals due to its rigid, heterocyclic structure.
• Chemical Biology Probes: Utilized to develop molecular probes and tags for studying biological processes and enzyme mechanisms.

Basic Information

Item	Details
Product Name	4-(1-Fluoro-1-Methyl-Ethyl)-Pyrimidine-5-Carbaldehyde
CAS No.	1427195-14-9
Molecular Formula	C8H9FN2O
Molecular Weight	168.17 g/mol
Synonyms	5-Formyl-4-(1-fluoro-1-methylethyl)pyrimidine; 4-(2-Fluoro-2-propyl)pyrimidine-5-carboxaldehyde; 4-(1-Fluoro-1-methylethyl)-5-pyrimidinecarboxaldehyde; 4-(α-Fluoroisopropyl)pyrimidine-5-carbaldehyde; 4-(2-Fluoro-2-propyl)-5-pyrimidinecarbaldehyde; 1427195-14-9; 4-(1-Fluoro-1-methylethyl)pyrimidine-5-carbaldehyde
EINECS	Contact for details

Quality Control

Every batch of 4-(1-Fluoro-1-Methyl-Ethyl)-Pyrimidine-5-Carbaldehyde is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent internal specifications, which are aligned with industry best practices for advanced pharmaceutical intermediates. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profile data is supplied with each shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.