Description

Cabazitaxel Acetone is a high-purity, semi-synthetic taxane derivative specifically designed for advanced pharmaceutical research and development. This compound is a critical intermediate in the synthesis of the potent chemotherapeutic agent Cabazitaxel, which is used to treat hormone-refractory metastatic prostate cancer. It is essential for pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in oncology drug development and production.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary use as a key intermediate in the commercial-scale manufacturing of Cabazitaxel API.
• Oncology Research: Serves as a crucial building block in preclinical and clinical research for developing novel taxane-based cancer therapies.
• Process Development & Optimization: Used by process chemists to develop, scale up, and optimize synthetic routes for Cabazitaxel production.
• Reference Standard: Acts as a high-purity analytical reference standard for quality control and method validation in pharmaceutical laboratories.
• Formulation Studies: Employed in the development of drug delivery systems, such as nanoparticle or liposomal formulations, for Cabazitaxel.
• Regulatory Filings: Provides the necessary quality-controlled material for inclusion in regulatory submission dossiers (e.g., for FDA, EMA).

Basic Information

Product Name	Cabazitaxel Acetone
CAS No.	1426815-65-7
Molecular Formula	C33H43NO8
Molecular Weight	581.70 g/mol
Synonyms	Cabazitaxel Acetone Solvate; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoyl]oxy}-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl (2R,3S)-3-amino-2-hydroxy-3-phenylpropanoate acetone solvate; Jevtana Intermediate; XRP6258 Acetone Solvate
EINECS	Contact for details

Quality Control

Our Cabazitaxel Acetone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting compliance with cGMP and ICH Q7 guidelines for active substance production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.