Description

4-Pyrimidinamine, 2-Methyl-6-[[(1S,2S)-2-(5-Methyl-2-Pyridinyl)Cyclopropyl]Methoxy]-n-[(5-Methyl-1,3,4-Thiadiazol-2-Yl)Methyl]- CAS NO 1424371-93-6 is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of critical importance for research and development in medicinal chemistry, particularly for the synthesis of novel therapeutic agents targeting specific biological pathways. It is primarily needed by pharmaceutical R&D laboratories, biotechnology firms, and contract research organizations (CROs) engaged in the development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel small-molecule drug candidates, particularly for oncology and antiviral research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties of lead compounds.
• API Development: Serves as a critical precursor in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Biochemical Tool Compound: Utilized in biochemical assays and as a probe to study specific enzyme inhibition or receptor modulation in early-stage drug discovery.
• Custom Synthesis: Employed by contract development and manufacturing organizations (CDMOs) for the custom synthesis of proprietary compounds for client projects.
• Process Chemistry Optimization: Used to develop and scale up efficient, cost-effective synthetic routes for potential commercial manufacturing.

Basic Information

Product Name	4-Pyrimidinamine, 2-Methyl-6-[[(1S,2S)-2-(5-Methyl-2-Pyridinyl)Cyclopropyl]Methoxy]-n-[(5-Methyl-1,3,4-Thiadiazol-2-Yl)Methyl]-
CAS No.	1424371-93-6
Molecular Formula	C21H24N6OS
Molecular Weight	408.52 g/mol
Synonyms	2-Methyl-6-[[(1S,2S)-2-(5-methyl-2-pyridinyl)cyclopropyl]methoxy]-N-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]-4-pyrimidinamine; (1S,2S)-2-(5-Methylpyridin-2-yl)cyclopropylmethyl 2-methyl-6-((5-methyl-1,3,4-thiadiazol-2-yl)methylamino)pyrimidin-4-yl ether; Advanced Pyrimidine-Thiadiazole Hybrid Intermediate; Complex Heterocyclic Amine Derivative; Pharmaceutical Building Block 1424371-93-6; N-[(5-Methyl-1,3,4-thiadiazol-2-yl)methyl]-2-methyl-6-{[(1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl]methoxy}pyrimidin-4-amine
EINECS	Contact for details

Quality Control

Our 4-Pyrimidinamine, 2-Methyl-6-[[(1S,2S)-2-(5-Methyl-2-Pyridinyl)Cyclopropyl]Methoxy]-n-[(5-Methyl-1,3,4-Thiadiazol-2-Yl)Methyl]- is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All batches undergo comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development projects with material produced under GMP-like controls for non-clinical and pre-clinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light). For long-term storage, consider storage under inert atmosphere at lower temperatures (e.g., -20°C) to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.