Description

Rip2 Kinase Inhibitor 1 CAS NO 1423186-80-4 is a potent and selective small molecule inhibitor targeting the Receptor-interacting protein 2 (RIP2) kinase, a key regulator in the NOD1/NOD2 signaling pathways involved in inflammatory and immune responses. This compound is a critical research tool for elucidating the role of RIP2 in various disease pathologies, including inflammatory bowel disease, psoriasis, and sarcoidosis. It is essential for pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in immunology, oncology, and autoimmune disease research.

Application

• Biochemical Research: Used as a selective pharmacological probe to study NOD1/NOD2-RIP2 signaling cascades in innate immunity.
• Drug Discovery & Development: Serves as a reference standard and lead compound for developing novel therapeutics targeting inflammatory and autoimmune disorders.
• Cellular Assays: Employed in in vitro cell-based assays to investigate the inhibition of RIP2 kinase and its downstream effects, such as NF-κB activation and cytokine production.
• Target Validation: Aids in validating RIP2 as a therapeutic target in preclinical models of chronic inflammation.
• Academic Research: Facilitates fundamental research in immunology and molecular biology departments to understand inflammatory pathway mechanisms.

Basic Information

Product Name	Rip2 Kinase Inhibitor 1
CAS No.	1423186-80-4
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	RIP2 Inhibitor 1; RIPK2 Inhibitor; GSK583; 5-(2,4-Difluorophenoxy)-N-(3-((3R,5S)-3,5-dimethylmorpholino)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-amine; 1H-Pyrrolo[2,3-b]pyridin-3-amine, 5-(2,4-difluorophenoxy)-N-[3-[(3R,5S)-3,5-dimethyl-4-morpholinyl]phenyl]-; GSK 583; RIP2 Kinase Inhibitor
EINECS	Contact for details

Quality Control

Our Rip2 Kinase Inhibitor 1 is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and our quality commitment ensures the material meets the stringent requirements for pharmaceutical and biochemical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.