Description

Cdki-73 is a potent and selective small-molecule inhibitor of cyclin-dependent kinase 9 (CDK9), a key regulator of transcription. This compound is a critical research tool for studying cell cycle control, transcription elongation, and oncogenic signaling pathways in various disease models. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology, virology, and molecular biology research.

Application

• Biomedical Research: A key reagent for investigating the role of CDK9 in cancer cell proliferation, apoptosis, and tumor progression.
• Drug Discovery & Development: Used as a reference compound or lead molecule in high-throughput screening and preclinical studies for novel CDK9-targeted therapeutics.
• Transcriptional Regulation Studies: Essential for probing mechanisms of RNA polymerase II-dependent transcription and short-lived oncoprotein stability (e.g., Mcl-1, Myc).
• Virology Research: Applied in studies of viral replication, particularly for viruses like HIV that depend on host transcriptional machinery regulated by CDK9.
• Signal Transduction Pathways: Used to dissect and validate specific kinase pathways involved in cellular differentiation and survival.
• Chemical Biology: Serves as a selective probe to understand CDK9-specific functions and validate its as a therapeutic target in complex biological systems.

Basic Information

Product Name	Cdki-73
CAS No.	1421693-22-2
Molecular Formula	C₂₀H₂₀N₈O
Molecular Weight	388.42 g/mol
Synonyms	CDK9 Inhibitor II; CDK9 Inhibitor-73; 2-((4-((4-Methylpiperazin-1-yl)methyl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; AT-7519 Analog; CDKi-73; CDK9i-73; CDK9 Inhibitor (Cdki-73); 1421693-22-2
EINECS	Contact for details

Quality Control

Our Cdki-73 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, identity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, HPLC chromatograms, and spectroscopic data is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (Mass Spec)	Consistent with molecular weight
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.