Description

2-[Carboxy(Difluoro)Methyl]Pyridine Hydrochloride, also known as 2,2-Difluoro-2-(Pyridin-2-Yl)Ethanoic Acid Hydrochloride, is a high-value, multifunctional fluorinated pyridine derivative. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block for synthesizing complex molecules. It is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where its unique difluoromethylcarboxylic acid moiety enables the introduction of desirable physicochemical properties into target compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting metabolic diseases, CNS disorders, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced materials with tailored surface properties and stability.
• Chemical Biology Probes: Utilized in the design of molecular probes and inhibitors for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis services catering to R&D and pilot-scale production needs.

Basic Information

Product Name	2-[Carboxy(Difluoro)Methyl]Pyridine Hydrochloride
CAS No.	1421603-45-3
Molecular Formula	C8H6F2NO2 • HCl
Molecular Weight	221.59 g/mol (Free acid) / 258.05 g/mol (HCl salt)
Synonyms	2,2-Difluoro-2-(pyridin-2-yl)ethanoic acid hydrochloride; 2-(Carboxy(difluoro)methyl)pyridine hydrochloride; 2-Pyridineacetic acid, α,α-difluoro-, hydrochloride; α,α-Difluoro-2-pyridineacetic acid hydrochloride; 2-(Difluorocarboxymethyl)pyridine HCl; Difluoro(pyridin-2-yl)acetic acid hydrochloride
EINECS	Contact for details

Quality Control

Our production of 2-[Carboxy(Difluoro)Methyl]Pyridine Hydrochloride adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting key parameters such as assay, impurity profile, and residual solvents. Our quality systems are designed to support cGMP compliance for pharmaceutical applications, and we welcome audits and specific quality agreements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.