Description

5-Bromo-8-Fluoro-6-Methyl-Quinoline is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceuticals and agrochemicals, where its unique halogenated quinoline scaffold enables precise molecular modifications. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and material science industries.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting kinase inhibition, anti-infective agents, and other therapeutic areas.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the quinoline core.
• Material Science: Acts as a building block for creating organic semiconductors, ligands for metal-organic frameworks (MOFs), and advanced functional materials.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and as a versatile scaffold for constructing complex heterocyclic libraries in medicinal chemistry.
• Academic & Contract Research: Essential for fundamental research in organic chemistry and for contract research organizations (CROs) developing custom synthesis routes.

Basic Information

Product Name	5-Bromo-8-Fluoro-6-Methyl-Quinoline
CAS No.	1420791-78-1
Molecular Formula	C₁₀H₇BrFN
Molecular Weight	240.07 g/mol
Synonyms	5-Bromo-8-fluoro-6-methylquinoline; 8-Fluoro-5-bromo-6-methylquinoline; Quinoline, 5-bromo-8-fluoro-6-methyl-; 6-Methyl-5-bromo-8-fluoroquinoline; 1420791-78-1 (CAS); 5-Br-8-F-6-Me-Quinoline
EINECS	Contact for details

Quality Control

Our 5-Bromo-8-Fluoro-6-Methyl-Quinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.