Description

7-Methyl Docetaxel is a semi-synthetic taxane derivative and a key intermediate in the development of novel chemotherapeutic agents. This compound is of significant interest for its potential role in creating next-generation oncology treatments with improved efficacy and safety profiles. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers focused on anticancer drug discovery and development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced taxane-based anticancer drugs and prodrugs.
• Oncology Research: Used as a reference standard and active material in preclinical studies to investigate structure-activity relationships (SAR) and mechanisms of action.
• Drug Discovery & Development: Employed in medicinal chemistry programs aimed at developing novel microtubule-stabilizing agents with enhanced properties.
• Process Chemistry: Acts as a key intermediate in the scale-up and optimization of synthetic routes for complex pharmaceutical active ingredients (APIs).
• Biochemical Research: Utilized in studies exploring tubulin polymerization dynamics and cellular resistance mechanisms in cancer models.

Basic Information

Item	Detail
Product Name	7-Methyl Docetaxel
CAS No.	1420767-25-4
Molecular Formula	C44H57NO14
Molecular Weight	823.93 g/mol
Synonyms	7-Methyl Docetaxel; 7-Methyl-Docetaxel; Docetaxel 7-Methyl Derivative; (2R,3S)-N-Carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate, 7-methyl-; 7-Methyltaxotere
EINECS	Contact for details

Quality Control

Our 7-Methyl Docetaxel is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.