Description

Lp-Pla2 -In-1 CAS NO 1420367-28-7 is a potent and selective small molecule inhibitor of Lipoprotein-associated Phospholipase A2 (Lp-PLA2), a key enzyme implicated in vascular inflammation and atherosclerosis. This high-purity compound is essential for pharmaceutical research and development, enabling critical studies into cardiovascular disease mechanisms and therapeutic interventions. It is primarily utilized by research institutions, pharmaceutical companies, and CROs engaged in preclinical drug discovery and biochemical assay development for inflammatory and cardiovascular targets.

Application

• Biochemical Research: Used as a selective tool compound to study the enzymatic activity, inhibition kinetics, and biological role of Lp-PLA2 in vitro.
• Cardiovascular Disease Research: Critical for investigating the pathophysiological role of Lp-PLA2 in atherosclerosis, plaque instability, and vascular inflammation.
• Drug Discovery & Screening: Serves as a reference standard and positive control in high-throughput screening (HTS) campaigns to identify novel Lp-PLA2 inhibitors.
• Pharmacology Studies: Employed in preclinical in vitro and ex vivo models to evaluate the efficacy and mechanism of action of potential therapeutic agents.
• Diagnostic Development Support: Used in the development and calibration of assays measuring Lp-PLA2 activity as a potential biomarker for cardiovascular risk.

Basic Information

Product Name	Lp-Pla2 -In-1
CAS No.	1420367-28-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Lp-PLA2 Inhibitor 1; Lp-PLA2-IN-1; 1420367-28-7; Lipoprotein-associated phospholipase A2 inhibitor; Lp-PLA2 inhibitor candidate; PLA2G7 inhibitor; Darapladib analog research compound
EINECS	Contact for details

Quality Control

Our Lp-Pla2 -In-1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and structural confirmation. A Certificate of Analysis (COA) detailing specific test results is provided with every shipment to guarantee traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert conditions for long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.