Description

3-Fluoro-4-Hydroxy-2-(Thiomethyl)Pyridine is a high-value, multi-functional heterocyclic building block featuring a unique combination of fluorine, hydroxyl, and thiomethyl substituents on a pyridine core. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and binding affinity. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in creating advanced intermediates for drug discovery programs targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel small molecule drugs, particularly in kinase inhibitor and central nervous system (CNS) therapeutic research.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom and heterocyclic structure contribute to biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis, leveraging the sulfur and nitrogen donor atoms.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials that require specific electronic or binding properties.
• Chemical Biology Probes: Utilized to build molecular probes for studying enzyme mechanisms and biological pathways due to its modifiable functional groups.

Basic Information

Product Name	3-Fluoro-4-Hydroxy-2-(Thiomethyl)Pyridine
CAS No.	1420034-41-8
Molecular Formula	C7H6FNO2S
Molecular Weight	187.19 g/mol
Synonyms	2-(Methylthio)-3-fluoro-4-hydroxypyridine; 3-Fluoro-4-hydroxy-2-(methylthio)pyridine; 4-Hydroxy-3-fluoro-2-(methylthio)pyridine; 3-Fluoro-4-hydroxy-2-methylthiopyridine; 3-Fluoro-4-pyridinol, 2-(methylthio)-; 2-Methylsulfanyl-3-fluoro-4-hydroxypyridine; 3-Fluoro-4-hydroxy-2-(methylsulfanyl)pyridine; 1420034-41-8
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-4-Hydroxy-2-(Thiomethyl)Pyridine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.