Description

tert-Butyl (4-(Difluoromethyl)Pyridin-2-Yl)Carbamate is a high-purity, advanced pharmaceutical intermediate featuring a protected amine group and a difluoromethyl-substituted pyridine ring. This compound is strategically important for medicinal chemistry research and development, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to introduce the difluoromethyl group, a common bioisostere.
• Agrochemical Synthesis: Serves as a precursor in the development of new-generation pesticides and herbicides with improved efficacy.
• Peptide Mimetics & PROTACs: The Boc-protected amine is valuable for constructing peptide-like molecules and proteolysis-targeting chimeras (PROTACs).
• Chemical Biology Probes: Employed in the creation of labeled compounds and probes for studying biological mechanisms and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.

Basic Information

Product Name	tert-Butyl (4-(Difluoromethyl)Pyridin-2-Yl)Carbamate
CAS No.	1419221-63-8
Molecular Formula	C12H16F2N2O2
Molecular Weight	258.26 g/mol
Synonyms	2-Pyridinecarboxamide, N-[(1,1-dimethylethoxy)carbonyl]-4-(difluoromethyl)-; Boc-4-(Difluoromethyl)-2-aminopyridine; tert-Butyl 4-(difluoromethyl)pyridin-2-ylcarbamate; N-Boc-2-Amino-4-(difluoromethyl)pyridine; 2-((tert-Butoxycarbonyl)amino)-4-(difluoromethyl)pyridine; 4-(Difluoromethyl)pyridin-2-amine, N-Boc protected; Boc-2-Amino-4-(difluoromethyl)pyridine; 1419221-63-8
EINECS	Contact for details

Quality Control

Our tert-Butyl (4-(Difluoromethyl)Pyridin-2-Yl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.