Description

Cilofexor is a potent and selective non-bile acid farnesoid X receptor (FXR) agonist, identified by the CAS registry number 1418274-28-8. This small molecule pharmaceutical intermediate is critical for the research and development of novel therapeutics targeting liver diseases, including primary biliary cholangitis (PBC) and nonalcoholic steatohepatitis (NASH). It is an essential building block for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in metabolic and liver disease drug discovery programs.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of active pharmaceutical ingredients (APIs) for clinical and pre-clinical studies.
• FXR-Targeted Drug Discovery: Serves as a key reference standard and starting material for developing new FXR agonist candidates.
• Metabolic Disease Research: Utilized in in vitro and in vivo studies to investigate pathways related to bile acid metabolism, inflammation, and fibrosis.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and pilot-scale manufacturing for new drug entities.
• Biochemical Assay Development: Acts as a control compound in high-throughput screening (HTS) assays to validate FXR receptor activity.

Basic Information

Product Name	Cilofexor
CAS No.	1418274-28-8
Molecular Formula	C₂₉H₂₈F₃N₃O₄
Molecular Weight	539.55 g/mol
Synonyms	GS-9674; PX-102; 3-((2-Chloro-4-(((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)carbonyl)phenyl)amino)-3-oxopropane-1-sulfonic acid; 4-[[(5-Cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy]carbonyl]-2-chloro-N-(3-sulfopropyl)aniline
EINECS	Contact for details

Quality Control

Our Cilofexor is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and rigorous control of residual solvents and impurities. Certificates of Analysis (COA) detailing batch-specific results are provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.